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After scouring the internet and digging through reams of text, we checked /var/qmail/queue/lock/trigger.
The trigger file did not look like it was supposed to (below).
It should look like this:
prompt# ls -l /var/qmail/queue/lock/trigger
prw–w–w- 1 qmails qmail 0 Dec 17 21:56 /var/qmail/queue/lock/trigger
The first character “p” in the `ls -l` output means that the file is a named pipe (or a “FIFO”). If it’s a regular file (“-“), doesn’t exist, or if the permissions are wrong, qmail-send won’t get an immediate notification when new messages are added to the queue, and it won’t process them until it hits its scheduled wake-up time, typically every 30 minutes.
Once we realized that this was the problem, it was easy to fix:
mkfifo /var/qmail/queue/lock/trigger
chown qmails:qmail /var/qmail/queue/lock/trigger
chmod 622 /var/qmail/queue/lock/trigger